David Brian Brown a travaillé sur plusieurs productions à Broadway, dont Days of Wine and Roses, Life of Pi, Mrs Doubtfire (prix Drama Desk), Moulin Rouge, Come From Away, Dear Evan Hansen, Frozen, Kiss Me Kate, Travesties, War Paint (prix Drama Desk), She Loves Me (finaliste aux prix Drama Desk), Curious Incident…, Gigi, Bridges of Madison County, If/Then, Macbeth, Death of a Salesman, Follies, Sister Act, Shrek, The Little Mermaid, Legally Blonde, Spamalot, Tarzan, Nine, Gypsy, Sweet Smell of Success, Aida, The Iceman Cometh, Chicago, Sideshow et Steel Pier. À l’écran, on a pu voir son travail dans Angels In America (finaliste aux prix Emmy), To Wong Foo…, It’s Complicated ainsi que Peter Pan Live! et The Sound of Music Live! sur NBC.